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Table 2 Relationship of demographic and clinical characteristics and cerebrospinal fluid (CSF) cytokine concentrations in 69 Ugandan children with cerebral malaria to CSF (a) KYNA and (b) kynurenine concentration

From: Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Characteristic Spearman’s rho value (95% CI) P
a
 Age −0.45 (−0.62,−0.24) 0.0001
 Sex −0.06 (−0.29, 0.18) 0.63
 Parasite density −0.01 (−0.25, 0.24) 0.94
 Lactate level 0.14 (−0.11, 0.37) 0.26
 Malaria retinopathy 0.15 (−0.09, 0.37) 0.23
 CSF IFN-γ 0.22 (−0.07, 0.47) 0.12
 CSF TNF 0.27 (0.03, 0.48) 0.03
b
 Age −0.34 (−0.53, −0.11) 0.004
 Sex −0.003 (−0.24, 0.24) 0.98
 Parasite density −0.09 (−0.33, 0.16) 0.46
 Lactate level 0.26 (0.01, 0.47) 0.04
 Malaria retinopathy 0.06 (−0.18, 0.30) 0.61
 CSF IFN-γ 0.22 (−0.06, 0.48) 0.11
 CSF TNF 0.30 (0.05, 0.50) 0.01