Table 2 Relationship of demographic and clinical characteristics and cerebrospinal fluid (CSF) cytokine concentrations in 69 Ugandan children with cerebral malaria to CSF (a) KYNA and (b) kynurenine concentration
Characteristic | Spearman’s rho value (95% CI) | P |
|---|---|---|
a | ||
Age | −0.45 (−0.62,−0.24) | 0.0001 |
Sex | −0.06 (−0.29, 0.18) | 0.63 |
Parasite density | −0.01 (−0.25, 0.24) | 0.94 |
Lactate level | 0.14 (−0.11, 0.37) | 0.26 |
Malaria retinopathy | 0.15 (−0.09, 0.37) | 0.23 |
CSF IFN-γ | 0.22 (−0.07, 0.47) | 0.12 |
CSF TNF | 0.27 (0.03, 0.48) | 0.03 |
b | ||
Age | −0.34 (−0.53, −0.11) | 0.004 |
Sex | −0.003 (−0.24, 0.24) | 0.98 |
Parasite density | −0.09 (−0.33, 0.16) | 0.46 |
Lactate level | 0.26 (0.01, 0.47) | 0.04 |
Malaria retinopathy | 0.06 (−0.18, 0.30) | 0.61 |
CSF IFN-γ | 0.22 (−0.06, 0.48) | 0.11 |
CSF TNF | 0.30 (0.05, 0.50) | 0.01 |