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Table 4 Relationship of (a) KYNA and (b) kynurenine levels with cognitive outcomes at 12-month follow-up in Ugandan children with cerebral malaria

From: Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Cognitive outcome

β coefficient (95% CI)a

P value

a

 Age <5 years, n = 40

  Overall cognitive ability

−0.6 (−2.6, 1.5)

0.57

  Attention

−0.2 (−0.7, 1.2)

0.60

Age ≥5 years, n = 22

  Overall cognitive ability

−0.5 (−2.8, 1.8)

0.63

  Attention

−2.1 (−4.9, −0.2)

0.03

b

 Age <5 years, n = 40

  Overall cognitive ability

−0.3 (−2.5, 2.0)

0.82

  Attention

−0.5 (−1.5, 0.5)

0.29

 Age ≥5 years, n = 22

  Overall cognitive ability

−1.8 (−3.7, 0.05)

0.056

  Attention

−2.5 (−4.0, −1.1)

0.003

  1. Log-transformed (base 10)
  2. aMultiple linear regression, adjusted for age and lactate level
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Malaria Journal

ISSN: 1475-2875

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