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Table 4 Relationship of (a) KYNA and (b) kynurenine levels with cognitive outcomes at 12-month follow-up in Ugandan children with cerebral malaria

From: Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Cognitive outcome β coefficient (95% CI)a P value
a
 Age <5 years, n = 40
  Overall cognitive ability −0.6 (−2.6, 1.5) 0.57
  Attention −0.2 (−0.7, 1.2) 0.60
Age ≥5 years, n = 22
  Overall cognitive ability −0.5 (−2.8, 1.8) 0.63
  Attention −2.1 (−4.9, −0.2) 0.03
b
 Age <5 years, n = 40
  Overall cognitive ability −0.3 (−2.5, 2.0) 0.82
  Attention −0.5 (−1.5, 0.5) 0.29
 Age ≥5 years, n = 22
  Overall cognitive ability −1.8 (−3.7, 0.05) 0.056
  Attention −2.5 (−4.0, −1.1) 0.003
  1. Log-transformed (base 10)
  2. aMultiple linear regression, adjusted for age and lactate level