Fig. 2From: Prevalence of polymorphisms in glucose-6-phosphate dehydrogenase, sickle haemoglobin and nitric oxide synthase genes and their relationship with incidence of uncomplicated malaria in Iganga, UgandaEffect of age on the relationship between G6PD deficiency and malaria incidence. A plot of incidence rates versus age for the different G6PD genotypes is shown. Incidence rates were highest among the G6PD c.202 G>A homozygotes (closed circles) and lowest among those without mutations (wildtypes shown by open circles). Heterozygous (G6PD c.202 G>A, open squares) children experienced malaria incidences less than the homozygous individuals. The adjusted incident rates ratios (aIRR) in reference to G6PD c.202 G>A wild-types for age 6 months to 1 year were; G6PD c.202 G>A homo/hemizygotes (aIRR = 1.54; 95% CI [0.689–3.434]; P = 0.29), G6PD c.202 G>A heterozygotes (aIRR = 1.48; 95% CI [0.838–2.604]; P = 0.18). Peak incidence rates among the homozygotes are seen among the 1–3 year olds {(aIRR = 2.32; 95% CI [1.509–3.559]; P = 0.000), G6PD c.202 G>A heterozygotes (aIRR = 1.01; 95% CI [0.629–1.608]; P = 0.98)}. Older homozygotes (5–9 years) showed the lowest incidence {(aIRR = 0.16; 95% CI [0.021–1.133]; P = 0.07), G6PD c.202 G>A heterozygotes (aIRR = 0.94; 95% CI [0.462–1.921]; P = 0.87). There were no homozygotes in the >3–5 age groupBack to article page