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Fig. 2 | Malaria Journal

Fig. 2

From: Prevalence of polymorphisms in glucose-6-phosphate dehydrogenase, sickle haemoglobin and nitric oxide synthase genes and their relationship with incidence of uncomplicated malaria in Iganga, Uganda

Fig. 2

Effect of age on the relationship between G6PD deficiency and malaria incidence. A plot of incidence rates versus age for the different G6PD genotypes is shown. Incidence rates were highest among the G6PD c.202 G>A homozygotes (closed circles) and lowest among those without mutations (wildtypes shown by open circles). Heterozygous (G6PD c.202 G>A, open squares) children experienced malaria incidences less than the homozygous individuals. The adjusted incident rates ratios (aIRR) in reference to G6PD c.202 G>A wild-types for age 6 months to 1 year were; G6PD c.202 G>A homo/hemizygotes (aIRR = 1.54; 95% CI [0.689–3.434]; P = 0.29), G6PD c.202 G>A heterozygotes (aIRR = 1.48; 95% CI [0.838–2.604]; P = 0.18). Peak incidence rates among the homozygotes are seen among the 1–3 year olds {(aIRR = 2.32; 95% CI [1.509–3.559]; P = 0.000), G6PD c.202 G>A heterozygotes (aIRR = 1.01; 95% CI [0.629–1.608]; P = 0.98)}. Older homozygotes (5–9 years) showed the lowest incidence {(aIRR = 0.16; 95% CI [0.021–1.133]; P = 0.07), G6PD c.202 G>A heterozygotes (aIRR = 0.94; 95% CI [0.462–1.921]; P = 0.87). There were no homozygotes in the >3–5 age group

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