Table 7 Frequency of molecular markers associated with resistance of Plasmodium falciparum to SP and AQ in the districts of Kita and Bafoulabe during the pre- and post-intervention surveys
Kita | Bafoulabe | p | |||
|---|---|---|---|---|---|
n/N | % | n | % | ||
Pre-intervention (July 2014) | |||||
dhfrN51I | 38/48 | 79.2 | 50/58 | 86.2 | 0.42 |
dhfrC59R | 39/48 | 81.2 | 54/58 | 93.1 | 0.07 |
dhfrS108 N | 42/48 | 87.5 | 53/58 | 91.4 | 0.59 |
Triple dhfr (N51I, C59R, S108N) | 37/48 | 77.1 | 49/58 | 84.8 | 0.45 |
dhps A437G | 20/48 | 41.8 | 23/56 | 42.0 | 0.95 |
dhps K540E | 6/48 | 12.5 | 2/58 | 3.4 | 0.11 |
Quintiple (triple dhfr+ dhpsA437G et K540E) | 2/48 | 4.2 | 1/56 | 1.8 | 0.41 |
Pfmdr1-86Y | 8/42 | 19.0 | 13/54 | 24.1 | 0.60 |
Pfcrt-76T | 44/48 | 91.7 | 51/57 | 89.5 | 0.25 |
Post intervention (December 2014) | |||||
dhfrN51I | 38/38 | 100 | 79/79 | 100 | 1 |
dhfrC59R | 38/38 | 100 | 77/79 | 97.5 | 0.46 |
dhfrS108N | 37/38 | 97.4 | 68/78 | 87.2 | 0.10 |
Triple dhfr (N51I, C59R, S108N) | 37/38 | 97.4 | 66/78 | 87.2 | 0.10 |
dhps A437G | 25/38 | 65.8 | 35/79 | 44.3 | 0.01 |
dhps K540E | 1/38 | 2.6 | 5/79 | 6.3 | 0.47 |
Quintuple (triple dhfr+ dhpsA437G et K540E) | 1/38 | 2.6 | 1/78 | 1.8 | 0.60 |
Pfmdr1-86Y | 7/38 | 18.4 | 8/79 | 10.1 | 0.60 |
Pfcrt-76T | 28/38 | 73.7 | 59/78 | 75.6 | 0.81 |