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Table 1 Performance characteristics of microscopy and RDT compared to PCR

From: Evaluation of CareStart™ Malaria HRP2/pLDH (Pf/pan) Combo Test in a malaria low transmission region of Senegal

 

PCR

Total

 

Positive

Negative

Microscopy

 Positive

137

0

137

 Negative

10

68

78

 Total

147

68

215

  

IC95%

 

Sensitivity (%)

93.2

[87.8–96.7]

 

Specificity (%)

100.0

[95.7–100]

 

PPV (%)

100.0

[97.8–100]

 

NPV (%)

87.2

[77.7–93.7]

 
 

PCR

Total

 

Positive

Negative

CareStart™RDT

 Positive

143

4

147

 Negative

4

64

68

 Total

147

68

215

  

IC95%

 

Sensitivity (%)

97.3

[93.2–99.3]

 

Specificity (%)

94.1

[85.6–98.4]

 

PPV (%)

97.3

[93.2–99.3]

 

NPV (%)

94.1

[85.6–98.4]

 
 

Test statistic

p values

 

Sensitivity comparison

6.0

0.0143

 

Specificity comparison

4.0

0.0455

 

PPV comparison

3.9

0.0487

 

NPV comparison

5.0

0.0251