From: Safety of primaquine given to people with G6PD deficiency: systematic review of prospective studies
Study (country) | Methods | Results | |
---|---|---|---|
Phenotype | Genotype | ||
Krudsood [24] (Thailand) | Not reported | G6PD normal: 134 patients G6PD deficient: 7 patients | Not tested |
Shekalaghe [22] (Tanzania) | PCR for G202A, A376G | G6PD normal: 77 patients G6PD deficient: 30 patients | G6PD wild type: 77 patients G6PD deficient heterozygous: 23 patients G6PD deficient hemizygous/homozygous: 7 patients |
Shekalaghe [23] (Tanzania) | PCR for G202A, A376G | G6PD normal: 493 patients G6PD deficient: 69 patients | G6PD wild type: 493 patients G6PD deficient heterozygous: 47 patients G6PD deficient hemizygous/homozygous: 22 patients |
Rueangweerayut [32] (Thailand) | PCR RFLP for Mahidol | G6PD normal (Mahidol negative with >80% G6PD activity): 6 patients G6PD deficient (G6PD enzyme activity 40–60% of normal): 6 patients | G6PD wild type: 6 patients G6PD deficient heterozygous: 6 patients |
(Uganda) | FST; PCR for G202A/A376G | G6PD normal: 373 patients G6PD deficient: 88 patients | G6PD wild type: 373 patients G6PD deficient heterozygous: 61 patients G6PD deficient hemizygous/homozygous: 27 patients |
Kheng [30] (Cambodia) | FST; enzyme quantification; PCR for Mahidol, Mediterranean, Coimbra, Chinese-5, and Canton | G6PD normal: 57 patients G6PD deficient: 18 patients | G6PD wild type: 57 patients G6PD deficient hemizygous male: 14 patients G6PD deficient homozygous female: 1 patient G6PD deficient heterozygous female: 3 patients |
Bancone [29] (Thai–Myanmar border) | FST; enzyme quantification; PCR RFLP for Mahidol. Chinese-4, Canton and Viangchan | G6PD normal: 1226 patients G6PD intermediate: 50 patients G6PD deficient: 124 patients | G6PD wild type: 1226 patients G6PD deficient hemizygous male: 39 patients G6PD deficient homozygous female: 5 patient G6PD deficient heterozygous female: 65 patients |
Ley [31] (Bangladesh) | FST; enzyme quantification | G6PD normal: 169 Mild G6PD deficiency: 5 patients Severe G6PD deficiency: 1 patient | Not tested |
Mwaiswelo [28] (Tanzania) | Rapid test; PCR for G202A, A376G | G6PD normal: 184 patients G6PD deficient: 33 patients | Males G6PD A wild type: 95 patients G6PD A− hemizygous: 15 patients |
Females G6PD AA and BA wild type: 83 patients G6PD A−A− homozygous: 5 patients G6PD AA− and BA−heterozygous: 22 patients |