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Fig. 1 | Malaria Journal

Fig. 1

From: Circulating microRNAs in malaria infection: bench to bedside

Fig. 1

Biogenesis and apoptotic bodies of miRNAs. a The miRNA genes are located mainly in the non-coding region of the genome and are firstly transcribed to primary microRNAs (pri-miRNAs). b Drosha enzyme cut pri-miRNAs to precursor microRNAs (pre-miRNAs) (45–140 nt) [25]. c Pre-miRNAs are transferred out of the nucleus with Exportin 5 and are digested at the hair pin loop part of pre-miRNA with Dicer. d The miRNA–miRNA* duplexes are split into two asymmetric strands. Mature single strand miRNAs are finally bound to miRNA-induced silencing complex (miRISC) [29]. e MiRNAs suppress the expression of the target genes via mRNA cleavage or translation repression. The functions of miRNAs are involved in development, differentiation, and apoptosis of the cells [30]

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