From: Circulating microRNAs in malaria infection: bench to bedside
Categories | Clinical or laboratory to diagnosis condition | Postulated miRNAs | Mechanism |
---|---|---|---|
Acidosis/acidemia | Artrial pH <7.3 or presence of acidosis | miR-210 | HIF-dependent trasncriptional regulation |
ARDS or pulmonary edema | The acute lung injury from noncardiogenic causes | miR-181b | NF-kB mediated vascular inflammation |
miR-125b | LPS-induced lung injury | ||
Cerebral malaria | Imparied consciousness or seizures | miR-210 | Regulation of the revascularization |
miR-27a, miR-23a | Brain activation by EFNA3, NP1 | ||
miR-150 | Stimulate angiogenic factors | ||
Renal failure | Urine output <0.4 ml/kg/hour or serum creatinine >3.0 mg/dl | miR 17–92 | Renal progenitors and renaly dysfuntion |
miR-24 | Apoptosis regulation | ||
Ongoing investigation | |||
 Anemia | Haemoglobin ≤8 g/dl | n.a. | – |
 Shock | Blood pressure <90/60 mmHg with the sign of cold, clammy extremities | n.a. | – |
 DIC | The presence of DIC phenomenon or spontaneous mucosal bleeding | n.a. | – |
 Hyperparasitemia | Presence of parasitized erythrocytes >10% | n.a. | – |
 Hypoglycemia | Presence of blood sugar <40 mg/dl | n.a. | – |
 Macroscopic hemoglobinuria | The presence of hemolysis in the patients without G6PD deficiency | n.a. | – |