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Table 2 Criteria for severe or complicated falciparum malaria infection [4,5,6,7] and candidate miRNAs

From: Circulating microRNAs in malaria infection: bench to bedside

Categories

Clinical or laboratory to diagnosis condition

Postulated miRNAs

Mechanism

Acidosis/acidemia

Artrial pH <7.3 or presence of acidosis

miR-210

HIF-dependent trasncriptional regulation

ARDS or pulmonary edema

The acute lung injury from noncardiogenic causes

miR-181b

NF-kB mediated vascular inflammation

miR-125b

LPS-induced lung injury

Cerebral malaria

Imparied consciousness or seizures

miR-210

Regulation of the revascularization

miR-27a, miR-23a

Brain activation by EFNA3, NP1

miR-150

Stimulate angiogenic factors

Renal failure

Urine output <0.4 ml/kg/hour or serum creatinine >3.0 mg/dl

miR 17–92

Renal progenitors and renaly dysfuntion

miR-24

Apoptosis regulation

Ongoing investigation

 Anemia

Haemoglobin ≤8 g/dl

n.a.

–

 Shock

Blood pressure <90/60 mmHg with the sign of cold, clammy extremities

n.a.

–

 DIC

The presence of DIC phenomenon or spontaneous mucosal bleeding

n.a.

–

 Hyperparasitemia

Presence of parasitized erythrocytes >10%

n.a.

–

 Hypoglycemia

Presence of blood sugar <40 mg/dl

n.a.

–

 Macroscopic hemoglobinuria

The presence of hemolysis in the patients without G6PD deficiency

n.a.

–

  1. ARDS Acute respiratory distress syndrome, DIC Disseminated intravascular coagulopathy, G6PD glucose-6-phosphate deficiency, n.a. not available data, HIF hypoxia-inducible factor, LPS lipopolysaccharide, EFNA3 epihrin-A3, NP1 neuronal pentraxin