Immunogenicity of the Plasmodium vivax merozoite surface protein 1 paralog in the induction of naturally acquired antibody and memory B cell responses

Table 1 A mass blood survey of the antibody responses to PvMSP1P-19 during acute phase and after recovery from P. vivax infection

Time point^a	Total (n)^b	No. positive (%)^c	OD values					Significance
Time point^a	Total (n)^b	No. positive (%)^c	Min^d	Max^e	Median^f	SD^g	P value^h	Significance
Acute phase	40	29 (72.5)	0.010	0.176	0.032	0.029	<0.0001	Acute vs healthy controls
3 months recovery	27	19 (70.4)	0.001	0.112	0.033	0.025	0.6681	Acute vs 3 months recovery
9 months recovery	28	19 (67.9)	0.001	0.093	0.032	0.023	0.7265	Acute vs 9 months recovery
12 months recovery	14	3 (21.4)	0.008	0.109	0.018	0.026	0.0067	Acute vs 12 months recovery

^a Time point the times at which the P. vivax-infected blood samples were collected
^b Total (n) the total numbers of samples collected at each time point
^c Number of positive (%) the number of seropositive individuals who had OD values greater than the cut-off value (mean ± 2 SD of the OD value of malaria-naïve individuals)
^d Min the lowest antibody level at each time point
^e Max the highest antibody level at each time point
^f Median the median OD value of antibody levels at each time point
^g SD the standard deviation of the antibody levels at each time point
^h P value P value of the difference between the mean antibody levels of P. vivax-infected subjects and malaria-naïve subjects that were compared using the Mann–Whitney U test

ISSN: 1475-2875