Skip to main content

Advertisement

Table 1 Analysis of oxylipins

From: The oxylipin and endocannabidome responses in acute phase Plasmodium falciparum malaria in children

Compound Abbreviation Precursor Pathway OPLS-DA uncomplicated versus controls p value uncomplicated versus controls OPLS-DA severe versus controls p value severe versus controls OPLS-DA severe versus uncomplicated p value severe versus uncomplicated
Thromboxane B2 TXB2 AA COX 0.62 <0.0001 0.55 0.0004 0.13 NS
9,12,13-trihydroxy-octadecenoic acid 9,12,13-TriHOME LA 5-LOX 0.36 NS 0.61 0.0022 0.31 NS
9,10,13-trihydroxy-octadecenoic acid 9,10,13-TriHOME LA 5-LOX 0.27 NS 0.61 0.0413 0.27 NS
Prostaglandin F2aα PGF AA COX −0.10 NS 0.00 0.0056 −0.02 NS
Prostaglandin E2 PGE2 AA COX 0.45 NS −0.37 0.0180 −0.19 NS
Prostaglandin D2 PGD2 AA COX 0.38 NS −0.21 0.0428 −0.03 NS
Resolvin D2 Resolvin D2 DHA 12/15-LOX 0.07 NS −0.17 NS −0.28 NS
Resolvin D1 Resolvin D1 DHA 12/15-LOX −0.32 −0.16 0.25
Lipoxin A4 5,6,-LXA4 AA 12/15-LOX −0.19 NS −0.10 NS −0.00 NS
Trans-Leukotriene B4 Trans-LTB4 AA 5-LOX −0.12 NS 0.18 NS 0.15 NS
Leukotriene B4 LTB4 AA 5-LOX −0.02 NS 0.56 NS 0.65 NS
12,13-dihydroxy-octadecenoic acid 12,13-DiHOME LA CYP 0.25 NS 0.34 NS 0.21 NS
9,10-dihydroxy-octadecenoic acid 9,10-DiHOME LA CYP 0.09 NS 0.34 NS 0.26 NS
14,15-dihydroxy-eicosatrienoic acid 14,15-DHET AA CYP 0.60 NS 0.58 NS −0.17 NS
11,12-dihydroxy-eicosatrienoic acid 11,12-DHET AA CYP 0.53 NS 0.40 NS −0.29 NS
8,9-dihydroxy-eicosatrienoic acid 8,9-DHET AA CYP 0.43 NS 0.21 NS −0.36 NS
5,6-dihydroxy-eicosatrienoic acid 5,6-DHET AA CYP −0.23 0.0054 −0.26 0.0051 0.23 NS
12-hydroxy-eicosapentaenoic acid 12-HEPE EPA 12/15-LOX −0.33 NS −0.36 NS −0.47 NS
20-hydroxy-eicosatetraenoic acid 20-HETE AA CYP 0.37 0.0017 0.27 0.0241 −0.33 NS
13-hydroxy-octadecadienoic acid 13-HODE LA 12/15-LOX 0.06 NS 0.55 NS 0.58 0.0200
9-hydroxy-octadecadienoic acid 9-HODE LA 5-LOX 0.09 NS 0.55 0.0350 (*) 0.57 0.0128 (*)
15-hydroxy-eicosatetraenoic acid 15-HETE AA 12/15-LOX −0.38 NS −0.23 0.0402 −0.25 NS
13-oxo-octadecadienoic acid 13-oxo-ODE LA 12/15-LOX 0.24 NS 0.51 NS 0.60 0.0464
11-hydroxy-eicosatetraenoic acid 11-HETE AA 12/15-LOX −0.37 NS −0.26 NS −0.19 NS
15-oxo-eicosatetraenoic acid 15-oxo-ETE AA 12/15-LOX −0.08 NS 0.29 NS 0.32 NS
12-hydroxy-eicosatetraenoic acid 12-HETE AA 12/15-LOX −0.37 NS −0.38 0.0079 −0.47 NS
8-hydroxy-eicosatetraenoic acid 8-HETE AA 12/15-LOX −0.13 NS 0.02 NS −0.11 NS
15-hydroxy-eicosatrienoic acid 15-HETrE DGLA 12/15-LOX 0.27 0.0306 −0.06 NS 0.11 NS
12-oxo-eicosatetraenoic acid 12-oxo-ETE AA 12/15-LOX 0.01 NS −0.14 NS −0.51 NS
9-hydroxy-eicosatetraenoic acid 9-HETE AA 12/15-LOX −0.28 NS −0.10 NS −0.10 NS
5-hydroxy-eicosatetraenoic acid 5-HETE AA 5-LOX −0.14 NS −0.01 NS −0.03 NS
12(13)epoxy-octadecenoic acid 12(13)-EpOME LA CYP 0.66 0.0087 0.72 0.0017 0.38 NS
14(15)-epoxy-eicosatrienoic acid 14(15)-EET AA CYP 0.60 NS 0.60 NS 0.26 NS
9(10)epoxy-octadecenoic acid 9(10)-EpOME LA CYP 0.69 0.0107 0.77 0.0025 0.39 NS
11(12)-epoxy-eicosatrienoic acid 11(12)-EET AA CYP 0.32 NS 0.46 NS 0.55 NS
5-oxo-eicosatetraenoic acid 5-oxo-ETE AA 5-LOX 0.09 NS 0.27 NS 0.01 NS
8(9)-epoxy-eicosatrienoic acid 8(9)-EET AA CYP 0.44 NS 0.44 NS 0.25 NS
5(6)-epoxy-eicosatrienoic acid 5(6)-EET AA CYP 0.54 NS 0.48 NS 0.29 NS
  1. p(corr) values from the OPLS-DA models between the studied groups of samples (the changes are presented in relation to infected individuals, with minus sign showing lower and plus sign depicting higher levels in infected individuals) and summary from the univariate t test analysis with Welch’s correction with p values provided for the compounds that showed significantly different levels (p < 0.05) between studied groups of samples; in italics are marked values significant according to the OPLS-DA models (jack-knifing confidence intervals) and according to t test with Bonferroni correction for p = 0.05 (0.00125)
  2. AA arachidonic acid, DHA docosahexaenoic acid, EPA eicosapentaenoic acid, GLA gamma-linolenic acid, LA linoleic acid
  3. * Non-parametric Mann–Whitney test