The oxylipin and endocannabidome responses in acute phase Plasmodium falciparum malaria in children

Malaria Journal

Table 2 Analysis of endocannabinoids

Compound	Abbreviation	Fatty acid precursor	OPLS-DA uncomplicated versus controls	p value uncomplicated versus controls	OPLS-DA severe versus controls	p value severe versus controls
2-Arachidonoyl glycerol	2-AG	AA	0.70	0.0048	0.70	0.0019
Arachidonoyl ethanolamide	AEA	AA	0.20	NS	0.43	NS
Oleoyl ethanolamide	OEA	OA	0.88	<0.0001	0.97	<0.0001
Palmitoyl ethanolamide	PEA	PA	0.80	0.0018	0.86	0.0001
Docosatetraenoyl ethanolamide	DEA	DTA	0.82	0.0009	0.83	0.0002
Arachidonoyl glycine	NAGLy	AA	−0.52	NS	−0.40	NS
Eicosapentaenoyl ethanolamide	EPEA	EPA	0.57	0.0017(*)	0.56	0.0006
Docosahexaenoyl ethanolamide	DHEA	DHA	0.56	0.0046	0.69	0.0025
Palmitoleoyl ethanolamide	POEA	PO	0.57	0.0145	0.52	0.0224
Linolenoyl ethanolamide	LEA	LA	0.36	NS	0.26	NS
Prostaglandin F2α ethanolamide	PGF2α EA	AA	−0.28	NS	0.02	NS
Prostaglandin E2 ethanolamide	PGE2 EA	AA	0.03	NS	0.15	NS

p(corr) values from the OPLS-DA models between the studied groups of samples (the changes are presented in relation to infected individuals, with minus sign showing lower and plus sign higher levels in infected individuals) and summary from the univariate t test analysis with Welch’s correction with p values provided for the compounds that showed significantly different levels (p < 0.05) between the studied groups of samples; in italics are marked values significant according to the OPLS-DA models and according to t test with Bonferroni correction (jack-knifing confidence intervals) for p = 0.05 (0.0042)
AA arachidonic acid, DHA docosahexaenoic acid, DTA docosatetraenoic acid, EPA eicosapentaenoic acid, LA linoleic acid, OA oleic acid, PA palmitic acid, PO palmitoleic acid
* Non-parametric Mann–Whitney test

ISSN: 1475-2875