Table 1 CYP3A4-392A>G and ABCB1 3435C>T genotype frequencies and D3 PCR positivity (IC95%)
From: The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
Gene/SNP | Genotype frequencies (IC 95%) | |||||
|---|---|---|---|---|---|---|
D3 positive | D3 negative | |||||
CYP3A4*1B | AA | AG | GG | AA | AG | GG |
3/48 (0.062; 0.016–0.182) | 14/48 (0.292; 0.174–0.443) | 31/48 (0.646; 0.440–0.775) | 8/49 (0.163; 0.078–0.302) | 21/49 (0.429; 0.291–0.577) | 20/49 (0.408; 0.270–0.558) | |
MDR1, c3435C>T | CC | CT | TT | CC | CT | TT |
34/47 (0.723; 0.571–0.839) | 9/47 (0.192; 0.097–0.337) | 4/47 (0.085; 0.028–0.213) | 41/51 (0.804; 0.665–0.897) | 7/51 (0.137; 0.062–0.269) | 3/51 (0.059; 0.015–0.172 | |