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Fig. 4 | Malaria Journal

Fig. 4

From: A model of Plasmodium vivax concealment based on Plasmodium cynomolgi infections in Macaca mulatta

Fig. 4

Backward extrapolation of the time trends in infected red blood cell (iRBC) populations for the five monkeys used in this study, namely: a RFa14, b Rsb14, c RIc14, d RFv13, and e RMe14. The data (blue dots) are well fitted by the modelled iRBCs in the blood (orange line). The pool of concealed iRBCs (grey line) is initially important, but its contribution to the total iRBC population becomes less significant later. The thick burgundy line indicates the time range of merozoite release from the liver, with dots representing, from left to right, scenarios where 1, 10, 100, or 1000 sporozoites, respectively, were successful in invading the liver and leading to the production of 20,000 merozoites each. As an example, if 100 sporozoites are successful, release from the liver is predicted to occur about 10 days after infection, except for a (RFa14 infection), where it is predicted to happen at about day 8

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