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Fig. 3 | Malaria Journal

Fig. 3

From: Integrative analysis associates monocytes with insufficient erythropoiesis during acute Plasmodium cynomolgi malaria in rhesus macaques

Fig. 3

Type I and Type II interferon transcriptional signatures are enriched in the bone marrow during acute malaria. a Pathways enriched with upregulated genes using GSEA. Pathways associated with interferons are highlighted in red. Bars indicate the negative logarithm base 10 of the p value of the enrichment for a given gene set. b Pathways enriched with upregulated genes using MetaCore. Pathways associated with interferons are highlighted in red. c Pathways enriched with downregulated genes using GSEA. d Pathways enriched with downregulated genes using MetaCore. e Clustered heatmap of transcriptional profiles of Type I IFN signature genes. Colours indicate z-score normalized expression values. f Clustered heatmap of transcriptional profiles of Type II IFN signature genes. g ifnγ BM expression levels. h IFNα serum concentrations. i IFNγ serum concentrations

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Malaria Journal

ISSN: 1475-2875

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