Fig. 5
Effect of T5 on parasite morphology in vitro. a Dose–response curve for T5 on synchronized P. falciparum parasites (FcB1 strain, 0–6 h post invasion, 48-h application) allowing IC50 determination on synchronized parasites. b Morphological alterations following T5 applications at various concentrations: 4, 20 and 40 µM, compared to an untreated control and E-64 (10 μM) treated parasites. Drug treatments were carried out on synchronized cultures (0–6 h post invasion) and morphological evaluations were done: 12, 24, 36 and 48 h after