Skip to main content

Advertisement

Table 2 Shows malaria diagnosis for 30 whole blood samples with the illumigene malaria assay in comparison with standard microscopy, RDT and PCR

From: Diagnostic performance of the loop-mediated isothermal amplification (LAMP) based illumigene® malaria assay in a non-endemic region

Sample Illumigene RDT Microscopy PCR Parasite density (parasites/µL)
Result Species
1 Pos Pos Pos Pos Pf + Po 1,027,798
2 Pos Pos Pos Pos Pf 292,432
3 Pos Pos Pos Pos Pv 68,129
4 Pos Pos Pos Pos Pf 27,731
5 Pos Pos Pos Pos Pv 7285
6 Pos Pos Pos Pos Pf 5917
7 Pos Pos Pos Pos Pf + Po 98
8 Pos Pos (*) Pos Pos Po 1496
9 Pos Neg Pos Pos Po 59
10 Pos Neg Pos Pos Pv 340
11 Pos Neg Pos Pos Pf 415
12 Pos Pos Neg − (#)
13 Neg Neg Neg /   
14 Neg Neg Neg /   
15 Neg Neg Neg /   
16 Neg Neg Neg /   
17 Neg Neg Neg /   
18 Neg Neg Neg /   
19 Neg Neg Neg /   
20 Neg Neg Neg /   
21 Neg Neg Neg /   
22 Neg Neg Neg /   
23 Neg Neg Neg /   
24 Neg Neg Neg /   
25 Neg Neg Neg /   
26 Neg Neg Neg /   
27 Neg Neg Neg /   
28 Neg Neg Neg /   
29 Neg Neg Neg /   
30 Neg Neg Neg /   
  1. Parasite density as quantified by microscopy on blood smear
  2. RDT, rapid diagnostic test; PCR, four-primer real-time PCR; Pf, Plasmodium falciparum; Pm, Plasmodium malariae; Po, Plasmodium ovale; Pv, Plasmodium vivax; Pos, positive; Neg, negative. –, missing data; (#), negative result with real-time PCR performed on thin blood smear, possibly due to inferior sample quality; (*), difficult to interpret (weak positive result); /, triple negative results (i.e. negative with RDT, microscopy and illumigene malaria assay) were not sent to the ITM for confirmation with real-time PCR