Table 1 Assigning outcomes for estimating treatment efficacy under current recommendations.
End-point for day X (X = 28 or 42) | Cumulative success or failure probability (Kaplan–Meier analysis) | Proportion (per-protocol analysis) |
|---|---|---|
Adequate clinical and parasitological response at day X | Success | Success |
Early treatment failure | Failure | Failure |
Late clinical failure before day 7 | Failure | Failure |
Late clinical failure or late parasitological failure on or after day 7 | ||
 Falciparum recrudescence | Failure | Failure |
 Falciparum reinfection | Censored day of reinfection | Excluded from analysis |
 Other species with falciparum recrudescence | Failure | Failure |
 Other species infection | Censored day of infection | Excluded from analysis |
 Undermined or indeterminate PCR | Excluded from PCR-corrected analysis | Excluded from analysis |
Loss to follow-up | Censored last day of follow-up according to timetable | Excluded from analysis |
Withdrawal and protocol violation | Censored last day of follow-up according to timetable before withdrawal or protocol violation | Excluded from analysis |