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Table 2 Pooled Kaplan–Meier estimates for recrudescence using naïve and metasurv approaches for AS + AQ [25]

From: Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges

Day Pooled Kaplan–Meier estimates
Naïve approacha D + L approach meta-analysisb
7 1.000 0.994 [0.987–1.000]
14 0.994 [0.989–1.000] 0.989 [0.979–0.998]
21 0.949 [0.933–0.966] 0.943 [0.916–0.970]
28 0.918 [0.895–0.941] 0.909 [0.873–0.948]
  1. aKaplan–Meier estimates were estimated assuming the data came from one single study. Patients with new infections, indeterminate outcomes and lost to follow-up were censored when deriving the K–M estimates for recrudescence failures
  2. bKaplan–Meier estimates and associated number of patients at risk were extracted on pre-scheduled follow-up days 1, 2, 3, 7, 14, 21, and 28. The estimates were pooled using MetaSurv package in R (Additional file 1: Section D). I squared statistic for heterogeneity = 0%