Fig. 4

Rapamycin modulates the recruitment of effector T cells to the brain. a Total number of leukocytes (in thousands, K) isolated from brains of mice treated with vehicle or rapamycin (5 mg/kg) on day 4 and collected on day 6 expressed per brain. b Total numbers with representative dot plots of CD4+ and CD8+ T cells from brains as determined by flow cytometry. CD4+ and CD8+ populations where gated from CD3 + cells; n = 5/group. c, d Total numbers with representative dot plots of activated CD4+ (c) and CD8+ (d) T cells from mice of the indicated treatment group on day 6 post infection. Data are mean ± SEM; n = 5/group