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Fig. 1 | Malaria Journal

Fig. 1

From: Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria

Fig. 1

Single dose CDDO-EA improves survival and prevents the development ECM without affecting parasitaemia. Seven to 9 weeks-old C57BL/6J mice were treated once, on day 4 post-infection, by intraperitoneal (ip) injection. CDDO-EA was administered at 200 μmol/kg, ART at 5 mg/kg. a Therapeutic treatment with CDDO-EA monotherapy significantly improved survival compared to vehicle control alone (χ2 = 7.70, p = 0.006, by log-rank test). Adjunctive therapy of CDDO-EA significantly improved survival above artesunate therapy alone (χ2 = 6.75, p = 0.009, by log-rank test, n = 15-20 mice per group). Data combined from two independent studies. b Treatment with CDDO-EA significantly reduced disease severity as determined by the RMBCS compared to treatment with artesunate alone 6, 7, 10, and 14 days post-infection (p = 0.048, by Kruskal–Wallis with Dunn’s correction, n = 5 mice per group). c Treatment with CDDO-EA had no impact on parasite burden. Parasitaemia was monitored using thin blood smears stained with Giemsa. CDDO-EA did not reduce parasitaemia

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