Fig. 3

Effect of CDDO-EA mono- and adjunctive therapy on cytokines during ECM. Factors were measured in plasma by ELISA on day 6 post-infection. Treatments were administered on day 4 post-infection (CDDO-EA administered at 200 μmol/kg, ART at 5 mg/kg, 4–5 mice per group, data from two independent studies). a Significantly lower levels of IL-10 were observed with adjunctive CDDO-EA therapy compared to vehicle alone (p = 0.003, Kruskal–Wallis test with Dunn’s correction). b A trend towards lower plasma TNF was observed on TNF levels with CDDO-EA therapy. c Significantly lower levels of IFN-γ levels were observed between CDDO-EA monotherapy (p = 0.032, Kruskal–Wallis test with Dunn’s correction) and adjunctive CDDO-therapy (p = 0.018, Kruskal–Wallis test with Dunn’s correction) compared to vehicle alone