Fig. 6
Adjunctive CDDO-treatment improves survival and neurological outcome over anti-malarial therapy alone. Seven to 9 weeks-old C57BL/6 mice were treated, on day 6 post-infection by single dose ip injection, after the onset of neurological symptoms of ECM. Data combined from two independent studies. a A significant difference in survival was observed between artesunate monotherapy and adjunctive CDDO-EA treatment (χ2 = 4.49, p = 0.0341, by log-rank test, n = 15–20 mice per group). b Significantly better neurological outcomes as determined by the RMBCS were observed for adjunctive CDDO-treatment compared to artesunate monotherapy (p = 0.032, 0.048, Mann–Whitney U test, 5 mice per group). RMBCS for day 6 were measured 16 h after injection