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Fig. 7 | Malaria Journal

Fig. 7

From: Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria

Fig. 7

Summary of the protective effects of CDDO-EA in ECM. Infection by P. berghei leads to oxidative stress and inflammation. CDDO-EA disrupts the interaction of Nrf2 and Keap1, allowing for the translocation of Nrf2 to the nucleus. With its binding partners, Nrf2 initiates the transcription of genes containing ARE elements in their promoters. In ECM, CDDO-EA treatment reduced levels of IL-10, TNF, INF-γ, Ang-2 while increasing levels of Ang-1, resulting in reduced BBB leak and improved survival

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Malaria Journal

ISSN: 1475-2875

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