Fig. 5

Distribution of the significant non-synonymous SNPs along amino acid sequence of K13, PI3K, PDE1, ARK2, ATG18 and ATG7 proteins. Domain structure of Kelch protein (K13), phosphatidylinositol 3-kinase (PI3K), cGMP-specific phosphodiesterase (PDE1), serine/threonine protein kinase (ARK2), autophagy related protein (Atg18 and Atg7), recovered from Pfam database server. Amino acid substitution and position in the protein are given for all non-synonymous mutations. Color code of mutations: black, not significant in any subpopulation; green, significant in only one subpopulation; red, significant mutations observed in several subpopulations