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Table 3 Early and late stage IC50 values and log IC50 values along with 95% confidence intervals (CI) for methylene blue against gametocytes produced from RKL-9 and JDP-8

From: Methylene blue induced morphological deformations in Plasmodium falciparum gametocytes: implications for transmission-blocking

Isolate

Early stage gametocytes

Late stage gametocytes

NM

Total

NM

Total

IC50 (95% CI)

log IC50 (95% CI)

IC50 (95% CI)

log IC50 (95% CI)

IC50 (95% CI)

log IC50 (95% CI)

IC50 (95% CI)

log IC50 (95% CI)

RKL-9

378.5 (239.1–599)

2.578 (2.379–2.777)

1069 (139.7–8180)

3.029 (2.145–3.913)

128.6 (71.06–232.9)

2.109 (1.852–2.367)

1235 (621.4–2455)

3.092 (2.793–3.390)

JDP-8

475.2 (318.2–709.7)

2.677 (2.503–2.851)

858.8 (477.5–1545)

2.934 (2.679–3.189)

88.09 (3.349–2317)

1.945 (0.5250–3.365)

910.1 (653.2–1268)

2.959 (2.815–3.103)

  1. Methylene blue demonstrated submicromolar IC50 values (NM) for both early and late stage gametocytes produced from RKL-9 and JDP-8 (All IC50 values are in nanomolar). No significant difference was observed between logarithm of IC50 values (NM and total) obtained for methylene blue against RKL-9 and JDP-8 (both early and late stage gametocytes) (p > 0.05)