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Table 4 Limits of stabilization (in weeks) for each chemical additive at different parasite densities; on improving the stability of HRP2, pLDH and aldolase present in dried P. falciparum-infected samples

From: Stabilization of RDT target antigens present in dried Plasmodium falciparum-infected samples for validating malaria rapid diagnostic tests at the point of care

Chemical additives HRP2 pLDH and aldolase
2000 P/µL 500 P/µL 200 P/µL 2000 P/µL 500 P/µL
Stability (in weeks) Percentage stability (%) Stability (in weeks) Percentage stability (%) Stability (in weeks) Percentage stability (%) Stability (in weeks) Percentage stability (%) Stability (in weeks) Percentage stability (%)
Sucrose 53 100 53 100 33 62 21 40 0 0
Glycerol/sucrose 33 62 33 62 21 40 18 34 18 34
Alsever’s/sucrose 53 100 53 100 53 100 12 23 2 4
Biostab/sucrose 53 100 53 100 53 100 2 4 2 4
Trehalose 53 100 53 100 43 81 43 81 21 40
Sucrose/trehalose 53 100 43 81 33 62 53 100 18 34
Glycerol/trehalose 53 100 24 45 24 45 12 23 10 19
Biostab/trehalose 53 100 53 100 53 100 24 45 2 4
LDH stabilizer 53 100 53 100 33 62 15 28 2 4
LDH stabilizer/trehalose 43 81 43 81 33 62 24 45 10 19
  1. P/µL, Parasites per microliter; pLDH, Plasmodium lactate dehydrogenase; HRP2, histidine rich protein II
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Malaria Journal

ISSN: 1475-2875

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