Fig. 4From: Global sequence diversity of the lactate dehydrogenase gene in Plasmodium falciparumAmino acid substitution sites on P. falciparum LDH in comparison with human LDH. Non-synonymous substitution positions (red) and synonymous substitution positions (blue) were marked on the putative LDH of P. falciparum 3D7 strain (amino acid residues 1–317). The yellow block represents the location of Plasmodium-specific extended amino acids: DKEWN (amino acid positions 90–94). Arrowheads indicate conserved catalytic and cofactor-binding amino acid residues (black) found in P. falciparum LDH. Corresponding amino acid residues in human LDH-A are shown in the bottom rowBack to article page