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Table 1 Single nucleotide polymorphisms (SNPs) in the gene encoding lactate dehydrogenase (LDH) of Plasmodium falciparum

From: Global sequence diversity of the lactate dehydrogenase gene in Plasmodium falciparum

Allele Isoform Nucleotide position (corresponding amino acid position)
36
(12)
73
(25)
85
(29)
259
(87)
399
(133)
407
(136)
450
(150)
451
(151)
513
(171)
560
(187)
563
(188)
783
(261)
814
(272)
858
(286)
891
(297)
L1a LDH-1 TCA
S
CAG
Q
GGA
G
GGA
G
GTA
V
TTA
L
TTA
L
GGT
G
CCA
P
GTT
V
CTT
L
TCA
S
GAT
D
GTT
V
GAG
E
L1b TCG
S
GAA
E
L1c CCC
P
GTC
V
L1d TTG
L
L1e TCG
S
L2 LDH-2 AAT
N
L3 LDH-3 AAG
K
L4 LDH-4 CGA
R
CGA
R
GTC
V
CGT
R
GGT
G
L5 LDH-5 TCA
S
CCT
P
  1. Positions of polymorphic nucleotides (underlined letter) in the ldh gene are numbered according to the ldh sequence of P. falciparum reference strain 3D7. Amino acid positions of LDH are shown in parentheses (bold, non-synonymous amino acid substitution; italic, synonymous substitution). A nucleotide substitution at position 15 (GCA/GCG) reported in P. falciparum Mzr-1 isolate from India (NCBI sequence ID: JN547219, [11]) was excluded in the present study. Dashes (–) indicate the nucleotide sequence of the L1a allele