Global sequence diversity of the lactate dehydrogenase gene in Plasmodium falciparum

Malaria Journal

Table 2 Geographical distribution of ldh alleles in natural isolates of Plasmodium falciparum

Origin of P. falciparum	L1a	L1b	L1c	L1d	L1e	L2	L3	L4	L5
Origin of P. falciparum	L1a	L1b	LDH-1	L1d	L1e	LDH-2	LDH-3	LDH-4	LDH-5
Cambodia^c	1	0	0	0	0	0	0	0	0
P. R. China^c	0	0	0	1	0	1	0	1	1
Indonesia^a	0 (133)^d	0	0	0	0	0	0	0	0
India^a	2 (46)^d	0	1	0	0	0	0	0	0
Iran^a	6	1	0	0	0	0	0	0	0
Laos^c	2	0	0	0	0	0	0	0	0
Malaysia^c	1	0	0	0	0	0	0	0	0
The Philippines^c	1	0	0	0	0	0	0	0	0
Thailand^b	53	0	0	0	0	0	0	0	0
Vietnam^c	3	0	0	0	0	0	0	0	0
The Gambia^c	54	0	0	0	0	11	0	0	0
Ghana^c	0	0	0	0	0	1	0	0	0
Madagascar^a	0 (126)^d	0	0	0	0	1	1	0	0
Mali^c	14	0	0	0	1	8	0	0	0
Mozambique^c	1	0	0	0	0	0	0	0	0
Senegal^c	54	0	0	0	0	8	0	0	0
Tanzania^c	1	0	0	0	0	0	0	0	0
Uganda^c	7	0	0	0	0	1	0	0	0
Brazil^c	4	0	0	0	0	0	0	0	0
Columbia^c	1	0	0	0	0	0	0	0	0
El Salvador^c	1	0	0	0	0	0	0	0	0
French Guiana^c	22	0	0	0	0	0	0	0	0
Honduras^c	2	0	0	0	0	0	0	0	0
Total	230	1	1	1	1	31	1	1	1

The numbers of nucleotide sequences from the PlasmoDB and NCBI databases are shown
^aPublished sequences of P. falciparum ldh in Indonesia, Madagascar, India and Iran were taken from the literature [11,12,13, 39]
^bSequence data of 50 P. falciparum isolates in the present study and 3 sequences of P. falciparum strain K1 submitted to the NCBI database
^cUnpublished nucleotide sequences of the ldh gene were retrieved from the PlasmoDB and NCBI databases and used to deduce the amino acid sequences (see Additional file 2)
^dNumbers in brackets indicate ldh sequences of P. falciparum that were identical to L1a of P. falciparum 3D7 which were reported in literature [11,12,13, 39], but without the NCBI sequence IDs

ISSN: 1475-2875