Skip to main content

Table 4 Genetic diversity of the gene encoding lactate dehydrogenase in malaria parasites of humans and non-human primates

From: Global sequence diversity of the lactate dehydrogenase gene in Plasmodium falciparum

Species Host n Size (bp) nsSNP sSNP Allele Isoform π
P. falciparum Homo sapiens 268 918 8 7 9 5 0.0004
P. vivax a Homo sapiens 49 931 21 10 11 9 0.0021
P. ovale b Homo sapiens 3 951 5 27 3 3 0.0208
P. malariae d Homo sapiens 1 898 ND ND 1 1 ND
P. praefalciparum c Gorilla gorilla gorilla 4 821 1 1 3 2 0.0013
P. alderi c Gorilla gorilla gorilla 4 770 0 3 4 1 0.0022
P. billcolinsi c Gorilla gorilla gorilla 1 770 ND ND 1 1 ND
P. reichenowi c Pan troglodytes 11 822 0 9 10 1 0.0025
P. gaboni c Pan troglodytes 15 770 1 9 14 3 0.0030
P. blacklocki c Pan troglodytes 3 770 1 1 3 2 0.0017
P. cynomolgi d Macaca fascicularis 1 770 ND ND 1 1 ND
P. knowlesi d Macaca fascicularis 1 770 ND ND 1 1 ND
  1. n number of nucleotide sequences, nsSNP non-synonymous SNsP, sSNP synonymous SNPs, ND not determined
  2. aldh sequences of P. vivax in South Korea, China, India and Iran were taken from the literature [11, 12, 18]
  3. bldh sequence of P. ovale strain Harding derived from Brown et al. [19]
  4. cldh sequences from gorilla and chimpanzee malaria parasites in Cameroon and Democratic Republic of Congo were taken from Liu et al. [20, 21]
  5. dUnpublished sequences deposited in the PlasmoDB database (see Additional file 3 for sequence ID)