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Table 4 Genetic diversity of the gene encoding lactate dehydrogenase in malaria parasites of humans and non-human primates

From: Global sequence diversity of the lactate dehydrogenase gene in Plasmodium falciparum

Species

Host

n

Size (bp)

nsSNP

sSNP

Allele

Isoform

π

P. falciparum

Homo sapiens

268

918

8

7

9

5

0.0004

P. vivax a

Homo sapiens

49

931

21

10

11

9

0.0021

P. ovale b

Homo sapiens

3

951

5

27

3

3

0.0208

P. malariae d

Homo sapiens

1

898

ND

ND

1

1

ND

P. praefalciparum c

Gorilla gorilla gorilla

4

821

1

1

3

2

0.0013

P. alderi c

Gorilla gorilla gorilla

4

770

0

3

4

1

0.0022

P. billcolinsi c

Gorilla gorilla gorilla

1

770

ND

ND

1

1

ND

P. reichenowi c

Pan troglodytes

11

822

0

9

10

1

0.0025

P. gaboni c

Pan troglodytes

15

770

1

9

14

3

0.0030

P. blacklocki c

Pan troglodytes

3

770

1

1

3

2

0.0017

P. cynomolgi d

Macaca fascicularis

1

770

ND

ND

1

1

ND

P. knowlesi d

Macaca fascicularis

1

770

ND

ND

1

1

ND

  1. n number of nucleotide sequences, nsSNP non-synonymous SNsP, sSNP synonymous SNPs, ND not determined
  2. aldh sequences of P. vivax in South Korea, China, India and Iran were taken from the literature [11, 12, 18]
  3. bldh sequence of P. ovale strain Harding derived from Brown et al. [19]
  4. cldh sequences from gorilla and chimpanzee malaria parasites in Cameroon and Democratic Republic of Congo were taken from Liu et al. [20, 21]
  5. dUnpublished sequences deposited in the PlasmoDB database (see Additional file 3 for sequence ID)