Fig. 8

Influence of dominance and resistance restoration on time-to-resistance for mixtures and sequences. Dominance of the allele coding for resistance to insecticide 1 is increased from row 1 (a, b) to row 2 (c, d). Resistance restoration for the allele coding for resistance to insecticide 1 is increased from column 1 (a, c) to column 2 (b, d). The ‘s’ and ‘m’ on the upper X axis and mix/seq in the lower right of each panel stand for sequence and mixture and are explained in the legend to Fig. 6. a All control inputs equal at 0.5, b resistance restoration for insecticide 1 increased from 0.5 to 0.8, c dominance for insecticide 1 increased to 0.8, d resistance restoration and dominance for insecticide 1 increased to 0.8. Changing dominance and resistance restoration does not change the relative ordering of mixtures and sequences, time-to-resistance remains longest for sequences in all four scenarios