Fig. 1

Structure and organization of RNASE3 gene (ECP) located on chromosome 14q112 (14q24-q31). a RNASE3 gene polymorphisms located on chromosome 14q112 (14q24-q31). b Linkage disequilibrium map of the RNASE3 gene provided by the software Haploview for RNASE3 polymorphisms. a Coding and untranslated regions are indicated by black and white rectangles respectively. Positions are numbered according to the initiation codon ATG considered as + 1 (indicated by a black triangle). The genomic sequence used for alignment is GenBank sequence NC_000014.9-GI 568815584. b Linkage disequilibrium map of the RNASE3 gene provided by the software Haploview. The LD plot shows pairwise D′ values given in the squares for each statistical comparison between the SNPs. The different shade of color represent D′ values (between 0 and 1). An empty red square indicates that D′ > 0.97. The Lewontin’s D′ coefficient is correlated with the level of recombination: it is useful for the finding of an haploblock