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Table 3 Allele frequencies and Hardy–Weinberg estimations of SNPs in the study population

From: Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population

Polymorphisms RNASE3 MAF (A1 frequency) HWE*
p value
Allele A1 African (NCBI db) Allele A1 European (NCBI db)
Location referred to ATG meth start NCBI dbSNP number A1 A2 Amino acid change SM UM CTR Global population
Promoter −550G/A rs2284954 A G 0.14 0.11 0.16 0.14 0.07 0.23 0.70
Promoter −399T/C* rs147413155 C T 0.08 0.03 0.03 0.04 0.02 0.04 0.00
Promoter −38C/A** rs2233859 A C 0.02 0.02 0.05 0.03 0.16 0.03 0.42
Coding +371_G/C rs2073342 G C Arg/Threo 0.46 0.4 0.34 0.41 0.08 0.37 0.71
3′utr +499_G/C rs2233860 C G 0.14 0.25 0.23 0.21 0.15 0.23 0.18
3′utr +577_A/T rs8019343 T A 0.23 0.19 0.18 0.21 0.83 0.83 0.001
  1. SM Severe malaria, UM Uncomplicated Malaria, CTR Control group HWEp Hardy–Weinberg in global group, p promoter region, c coding region, u untranslated region
  2. * Deviation from Hardy–Weinberg, with values p < 0.012 (corrected threshold)
  3. ** Minor Allele frequency in Global population (MAF) < 0.05