Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population

Malaria Journal

Table 3 Allele frequencies and Hardy–Weinberg estimations of SNPs in the study population

Polymorphisms RNASE3					MAF (A1 frequency)				HWE* p value	Allele A1 African (NCBI db)	Allele A1 European (NCBI db)
Location referred to ATG meth start	NCBI dbSNP number	A1	A2	Amino acid change	SM	UM	CTR	Global population	HWE* p value	Allele A1 African (NCBI db)	Allele A1 European (NCBI db)
Promoter −550G/A	rs2284954	A	G	–	0.14	0.11	0.16	0.14	0.07	0.23	0.70
Promoter −399T/C*	rs147413155	C	T	–	0.08	0.03	0.03	0.04	0.02	0.04	0.00
Promoter −38C/A**	rs2233859	A	C	–	0.02	0.02	0.05	0.03	0.16	0.03	0.42
Coding +371_G/C	rs2073342	G	C	Arg/Threo	0.46	0.4	0.34	0.41	0.08	0.37	0.71
3′utr +499_G/C	rs2233860	C	G	–	0.14	0.25	0.23	0.21	0.15	0.23	0.18
3′utr +577_A/T	rs8019343	T	A	–	0.23	0.19	0.18	0.21	0.83	0.83	0.001

SM Severe malaria, UM Uncomplicated Malaria, CTR Control group HWEp Hardy–Weinberg in global group, p promoter region, c coding region, u untranslated region
* Deviation from Hardy–Weinberg, with values p < 0.012 (corrected threshold)
** Minor Allele frequency in Global population (MAF) < 0.05

ISSN: 1475-2875