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Table 4 Single Nucleotide Polymorphism (SNP) and association analysis with susceptibility to severe malaria (SM)

From: Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population

NCBI dbSNP number Phénotype MAF Nominal p values for statistical test (additive models)
SM UM CTR All SM vs. UM UM vs. CTR SM vs. CTR
A. Hb S and Hb C polymorphisms and association with SM
 rs334 A > T
OR (95% CI)
HbS 0.026 0.069 0.035 0.050 0.033
2.67 (2.013.5)
0.257 0.446
 rs33930165 G > A
OR (95% CI)
HbC 0.000 0.009 0.029 0.011 0.258 0.1661 0.0084
1.67 (0.993.42)
 rs713040 C > T
OR (95% CI)
  0.107 0.068 0.119 0.099 0.097 0.029
2.33 (1.557.33)
0.660
RNASE3 SNPs Nominal p values for statistical test
Position (NCBI Ids) Associated allele UM vs. CTR SM vs. CTR SM vs. UM SM vs. UM + CTR
ADD D/R ADD D/R ADD D/R ADD D/R
B. Association analysis with susceptibility to severe malaria under Hb polymorphisms corrections
 Promoter −550G/A (rs2284954) A 0.30   0.81   0.71   0.84  
 Promoter −399T/C (rs147413155) C 0.36   0.28   0.55   0.23  
 Promoter −38C/A (rs2233859) A 0.38   0.29   0. 98   0.47  
 Coding +371_G/C (rs2073342)
OR (95% CI)
G 0.08
1.8 (0.350.91)
0.01 (D)
3.9 (1.2911.7)
0.05
1.78 (0.993.1)
0.08 (D)
2.18 (0.885.36)
0.86   0.17  
 3′utr + 499_G/C (rs2233860)
OR (95% CI)
C 0.52   0.05
1.46 (1.212.09)
0.01 (D)
1.30 (1.111.79)
0.003
1.43 (1.201.92)
0.01 (D)
1.28 (1.101.76)
0.001
1.50 (1.301.84)
0.004 (D)
1.29 (1.211.74)
 3′utr + 577_A/T (rs8019343) T 0.66   0.16   0.17   0.06
1.83 (0.96–3.05)
0.07(D)
1.98 (0.92–4.32)
  1. For each polymorphism, the p values for statistical tests were indicated. Statistical tests used were logistic regression analysis. (A) Association analysis for HB polymorphisms by comparison of SM vs Controls group B) RNASE3 polymorphisms association analysis adjusted for HbS polymorphisms (rs334 A > T) (B). The associated allele of polymorphism is given. The calculation modes for logistic regression test are indicated using different models (ADD additive, D Dominant, R Recessive modes). Borderline (0.05 ≤ p ≤ 0.1) and significant (0 ≤ p ≤ 0.05) p values are in bold. The p values for the dominant/recessive mode were showed only when lower than 0.1. (* Bonferroni corrections were not performed on p values). The OR (odds ratio) and CI (Confidence intervals) were showed when p values are significant or in borderline and were reprented in italic