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Table 2 Prevalence of pfk13 and pfmdr1 polymorphisms from pretreatment and day of late treatment failure observed during therapeutic efficacy monitoring in Angola, 2015

From: Prevalence of molecular markers of artemisinin and lumefantrine resistance among patients with uncomplicated Plasmodium falciparum malaria in three provinces in Angola, 2015

Genetic markers Pretreatment Day of late treatment failure
Benguela Lunda Sul Zaire Total Benguela Lunda Sul Zaire Total
pfk13 n = 188 n = 82 n = 199 n = 469 n = 15  n = 0 n = 35 n = 50
 Wild type 188 (100%) 80 (98%) 198 (99%)b 466 (99%) 15 (100%) 0 35 (100%)c 50 (100%)
 A578S 0 2 (2%) 1 (< 1%) (< 1%) 0 0 0 0
pfmdr1 copy number n = 195 n = 99 n = 203 n = 497 n = 15 0 n = 31 n = 46
 1 195 (100%) 99 (100%) 203 (100%) 497 (100%) 15 (100%) 0 31 (100%) 46 (100%)
pfmdr1 haplotypesa n = 194 n = 96 n = 201 n = 491 n = 15  0 n = 35 n = 50
 NYD 133 (69%) 68 (71%) 106 (54%) 308 (63%) 12 (80%) 0 21 (60%) 33 (66%)
 YYD 25 (13%) 6 (6%) 31 (16%) 62 (13%) 0 0 1 (3%) 1 (2%)
 NFD 49 (25%) 34 (35%) 74 (37%) 157 (32%) 5 (33%) 0 13 (37%) 18 (36%)
 YFD 1 (< 1%) 1 (1%) 13 (7%) 15 (3%) 0 0 1 (3%) 1 (2%)
 YYY 0 0 6 (3%) 6 (1%) 1 (7%) 0 0 1 (2%)
 NYY 0 0 1 (< 1%) 1 (< 1%) 0 0 0 0
 YFY 0 0 1 (< 1%) 1 (< 1%) 0 0 0 0
  1. aParticipants with mixed infections were included in the numerator for each haplotype 86, 184, 1246 observed; pfmdr1 haplotypes are N86Y, Y184F, D1246Y
  2. bIncludes one sample with synonymous mutation T535T
  3. cIncludes one sample with synonymous mutation T535T and one with synonymous mutation P553P