Prevalence of molecular markers of artemisinin and lumefantrine resistance among patients with uncomplicated Plasmodium falciparum malaria in three provinces in Angola, 2015

Table 2 Prevalence of pfk13 and pfmdr1 polymorphisms from pretreatment and day of late treatment failure observed during therapeutic efficacy monitoring in Angola, 2015

Genetic markers	Pretreatment				Day of late treatment failure
Genetic markers	Benguela	Lunda Sul	Zaire	Total	Benguela	Lunda Sul	Zaire	Total
pfk13	n = 188	n = 82	n = 199	n = 469	n = 15	n = 0	n = 35	n = 50
Wild type	188 (100%)	80 (98%)	198 (99%)^b	466 (99%)	15 (100%)	0	35 (100%)^c	50 (100%)
A578S	0	2 (2%)	1 (< 1%)	(< 1%)	0	0	0	0
pfmdr1 copy number	n = 195	n = 99	n = 203	n = 497	n = 15	0	n = 31	n = 46
1	195 (100%)	99 (100%)	203 (100%)	497 (100%)	15 (100%)	0	31 (100%)	46 (100%)
pfmdr1 haplotypes^a	n = 194	n = 96	n = 201	n = 491	n = 15	0	n = 35	n = 50
NYD	133 (69%)	68 (71%)	106 (54%)	308 (63%)	12 (80%)	0	21 (60%)	33 (66%)
YYD	25 (13%)	6 (6%)	31 (16%)	62 (13%)	0	0	1 (3%)	1 (2%)
NFD	49 (25%)	34 (35%)	74 (37%)	157 (32%)	5 (33%)	0	13 (37%)	18 (36%)
YFD	1 (< 1%)	1 (1%)	13 (7%)	15 (3%)	0	0	1 (3%)	1 (2%)
YYY	0	0	6 (3%)	6 (1%)	1 (7%)	0	0	1 (2%)
NYY	0	0	1 (< 1%)	1 (< 1%)	0	0	0	0
YFY	0	0	1 (< 1%)	1 (< 1%)	0	0	0	0

^aParticipants with mixed infections were included in the numerator for each haplotype 86, 184, 1246 observed; pfmdr1 haplotypes are N86Y, Y184F, D1246Y
^bIncludes one sample with synonymous mutation T535T
^cIncludes one sample with synonymous mutation T535T and one with synonymous mutation P553P

ISSN: 1475-2875