Table 1 Sequence polymorphisms in pfdhfr, pfdhps and pfmdr1 genes
Marker | Category | Haplotype | Number | Prevalence |
|---|---|---|---|---|
pfdhfr 51,59,108 | Wild type | NCS | 32 | 0.27 |
Single mutant | ICS | 3 | 0.03 | |
NCN | 4 | 0.03 | ||
Double mutant | IRS | 1 | 0.01 | |
NRN | 3 | 0.03 | ||
ICN | 8 | 0.07 | ||
Triple Mutant | IRN | 67 | 0.57 | |
pfdhps 437,540, 581, 613 | Wild type | AKAA | 14 | 0.14 |
Single mutant | GKAA | 66 | 0.67 | |
AKAS | 4 | 0.04 | ||
AKGA | 1 | 0.01 | ||
Double mutant | GKAS | 14 | 0.14 | |
Triple mutant | GKGS | 9 | 0.08 | |
pfmdr1 86,184,1042,1246 | Wild type | NFND | 63 | 0.52 |
Single mutant | YFND | 2 | 0.02 | |
NYND | 38 | 0.31 | ||
Double mutant | NFDD | 5 | 0.04 | |
NFNY | 3 | 0.03 | ||
YYND | 5 | 0.04 | ||
NYDD | 1 | 0.01 | ||
NYNY | 1 | 0.01 | ||
NFDY | 1 | 0.01 |