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Table 3 Antibodies seropositivity at enrollment, gestational week 30–32 and delivery

From: Antibody levels to recombinant VAR2CSA domains vary with Plasmodium falciparum parasitaemia, gestational age, and gravidity, but do not predict pregnancy outcomes

  Domain Primigravid (%) Secundigravid (%) Multigravid (%)
Enrollment   n = 157 n = 118 n = 328
DBL2 (FCR3 allele) 81.5 83.1 84.8
ID1-DBL2-ID2a (M1010 allele) 61.1 64.4 67.7
DBL3 (FCR3 allele) 73.9a 85.6 93.9
DBL3-4 (FCR3 allele) 75.8a 77.1 89.9
DBL4 (3D7 allele) 42.0 48.3 53.4
DBL4 (FCR3 allele) 74.5 71.2a 86.9
DBL4 (M1010 allele) 91.7 91.5 97.6
DBL4 (M711 allele) 71.3 72.0 82.9
DBL5 (FCR3 allele) 75.8a 82.2 92.7
DBL5 (M1010 allele) 87.3a 94.1 97.6
DBL5 (M466 allele) 89.8 96.6 96.3
GARP 77.7 72.9 76.5
Gestational week 30-32   n = 109 n = 83 n = 245
DBL2 (FCR3 allele) 77.1 75.9 83.7
ID1-DBL2-ID2a (M1010 allele) 47.7 55.4 62.0
DBL3 (FCR3 allele) 76.1a 79.5 93.5
DBL3-4 (FCR3 allele) 74.3 80.7 86.5
DBL4 (3D7 allele) 34.9 47.0 51.0
DBL4 (FCR3 allele) 76.1 73.5 81.2
DBL4 (M1010 allele) 90.8 95.2 96.7
DBL4 (M711 allele) 70.6 74.7 79.6
DBL5 (FCR3 allele) 73.4a 80.7 91.8
DBL5 (M1010 allele) 87.2 92.8 95.9
DBL5 (M466 allele) 93.6 94.0 96.3
GARP 64.2 68.7 74.3
Delivery   n = 152 n = 114 n = 324
DBL2 (FCR3 allele) 75.7 81.6 81.8
ID1-DBL2-ID2a (M1010 allele) 48.7 60.5 59.9
DBL3 (FCR3 allele) 77.6a 81.6 93.5
DBL3-4 (FCR3 allele) 72.4a 80.7 87.7
DBL4 (3D7 allele) 35.5a 50.9 54.3
DBL4 (FCR3 allele) 72.4 71.9 83.6
DBL4 (M1010 allele) 90.8 91.2 95.4
DBL4 (M711 allele) 68.4 73.7 80.6
DBL5 (FCR3 allele) 76.3a 78.9 90.7
DBL5 (M1010 allele) 88.2 90.4 94.8
DBL5 (M466 allele) 90.8 93.9 96.0
GARP 64.5 64.0 69.4
  1. aSeropositivity significantly lower compared to multigravidae, adjusted p value < 0.05