Assessment of asymptomatic Plasmodium spp. infection by detection of parasite DNA in residents of an extra-Amazonian region of Brazil

Table 3 Parameters used to calculate R₀ for the mathematical model

Parameter	Estimate	Basis for the estimate
N	15 inhabitants/km²	Value obtained by dividing the rural population in 2010 by the area of the municipality based on Brazilian Institute of Geography and Statistics (IBGE) figures [52]
M	10,815 specimens/km²	Value obtained from entomological studies carried out in the area [36, 37] and by applying linear regression following Zippin [53]
μ	0.68	Bona and Navarro-Silva [54]
T_MH	0.022	Chitnis et al. [55]; Nedelman [56]
T_HM	0.24	Chitnis et al. [55]; Nedelman [56]
γ	0.0055 (180 days)	Value obtained from the observed frequency of asymptomatic individuals and the results reported by Chitnis et al. [55]
b	0.5	Santos [57]; Laporta et al. [58]
q	10 days	Chitnis et al. 2008 [55]
p	8 days	Santos [57]; Laporta et al. [58]

N Estimated population size, M Abundance of An. cruzii, µ Mortality rate of A. cruzii, T_MH Probability of transmission of Plasmodium from An. cruzii to humans, T_HM Probability of transmission of Plasmodium from humans to A. cruzii, γ Human recovery rate, b Average An. cruzii daily biting rate, q Incubation period for P. vivax in humans, p Extrinsic incubation period for P. vivax

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