Fig. 5

Antibody responses in CPS-CQ-immunized DRAGA mice. a DRAGA mice (n = 5, mouse # 3–7) were immunized with CPS-CQ three times at 2 weeks interval. Three weeks after the last immunization serum levels of human IgM and IgG antibodies to Pfspz and iRBCs were measured by IFA. Dots show values in individual mice. Student paired t test p value is indicated over the histogram. b Human IgM (left) and IgG (middle) antibody titers to the Pfspz negatively correlated with the frequency of human splenic Tregs. In contrast there was no negative correlation between the antibody titers to iRBCs and the Treg frequency (right panel). Spearman’s R values are shown over the histograms