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Fig. 6 | Malaria Journal

Fig. 6

From: Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity

Fig. 6

CPS-CQ immunization protects DRAGA mice against challenge with Pfspz, but not against challenge with iRBCs. a DRAGA mice (n = 5) were immunized with CPS-CQ three times at 2 weeks interval. Three weeks after the last immunization, mice were challenged intravenously with infectious P. falciparum sporozoites (105 per mouse). Control mice were treated with CQ alone (n = 3) or they were untreated (infectivity controls, n = 5) and challenged as above. Mice were followed for blood stage parasitaemia by PCR using primers specific for P. falciparum 18S rRNA. Data present the percentage of parasitaemic mice. b Kinetics of total human antibody titers to Pfspz (upper panel) and to iRBCs (lower panel) in CPS-CQ immunized mice as in a. Antibody titers in protected mice are shown in blue and antibody titers for the unprotected mouse is shown in red. c Parasitaemia measured by qPCR using primers specific for P. falciparum 18S rRNA in DRAGA mice immunized with CPS-CQ (n = 3) or treated with CQ alone (n = 3) that were challenged intravenously with iRBCs (7 × 105/mouse)

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