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Table 2 Treatment provided (in mg/kg bodyweight)

From: Low risk of recurrence following artesunate–Sulphadoxine–pyrimethamine plus primaquine for uncomplicated Plasmodium falciparum and Plasmodium vivax infections in the Republic of the Sudan

 

Artesunate

Sulphadoxine

Pyrimethamine

Primaquineb

Target dose [13]

4 mg/kg per day for 3 days (range 2–10 mg/kg)

25 mg/kg single dose (range 25–70 mg/kg)

1.25 mg/kg single dose (range 1.25–3.5 mg/kg)

0.25 mg/kg or 3.5 total dose

P. falciparum (n = 231)

 Mean total dose received in mg/kg (95% CI)

10.3 (9.77–10.74)

34.26 (31.37–37.15)

1.7 (1.57–1.86)

0.28 (0.254–0.305)

 Median total dose received in mg/kg (IQR, range)

9. 23 (7.69–12.00, 5.36–25.00)

25.42 (19.23–41.67, 13.39–115.38)

1.3 (0.96–2.08, 0.67–5.77)

0.25 (0.192–0.333, 0.000–0.789)

 N (%) patients with suboptimal dosagea

0 (0.0%)

104 (45.0%)

104 (45.0%)

5 (4.2)

P. vivax/mixed infection (n = 78)

 Mean total dose received in mg/kg (95% CI)

10.9 (10.32–11.64)

39.3 (34.76–43.89)

2.0 (1.74–2.2.)

4.2 (3.57–4.86)

 Median total dose received in mg/kg (IQR, range)

10.81 (9.23–7.06, 6.12–27.78)

30.0 (23.07– 55.56, 15.31–111.11)

1.5 (1/15–2.78, 0.77–5.56)

4.2 (3.18–4.67, 0.12–11.67)

 N (%) patients with suboptimal dosagea

0 (0.0%)

21 (26.9)

21 (26.9)

6 (15.4%)

  1. aSuboptimal dosage was defined as a total dose below 4 mg/kg AS, below 25 mg/kg sulphadoxine, below 1.25 mg/kg pyrimethamine and below 0.15 mg/kg (Pf) or 2.5 mg/kg (Pv) primaquine
  2. bOnly patients from Pf-PQ arm (n = 119, 0.25 mg/kgBW) and Pv-PQ14 (n = 39, 3.5 mg/kgBW) arm included