Artesunate | Sulphadoxine | Pyrimethamine | Primaquineb | |
---|---|---|---|---|
Target dose [13] | 4 mg/kg per day for 3 days (range 2–10 mg/kg) | 25 mg/kg single dose (range 25–70 mg/kg) | 1.25 mg/kg single dose (range 1.25–3.5 mg/kg) | 0.25 mg/kg or 3.5 total dose |
P. falciparum (n = 231) | ||||
Mean total dose received in mg/kg (95% CI) | 10.3 (9.77–10.74) | 34.26 (31.37–37.15) | 1.7 (1.57–1.86) | 0.28 (0.254–0.305) |
Median total dose received in mg/kg (IQR, range) | 9. 23 (7.69–12.00, 5.36–25.00) | 25.42 (19.23–41.67, 13.39–115.38) | 1.3 (0.96–2.08, 0.67–5.77) | 0.25 (0.192–0.333, 0.000–0.789) |
N (%) patients with suboptimal dosagea | 0 (0.0%) | 104 (45.0%) | 104 (45.0%) | 5 (4.2) |
P. vivax/mixed infection (n = 78) | ||||
Mean total dose received in mg/kg (95% CI) | 10.9 (10.32–11.64) | 39.3 (34.76–43.89) | 2.0 (1.74–2.2.) | 4.2 (3.57–4.86) |
Median total dose received in mg/kg (IQR, range) | 10.81 (9.23–7.06, 6.12–27.78) | 30.0 (23.07– 55.56, 15.31–111.11) | 1.5 (1/15–2.78, 0.77–5.56) | 4.2 (3.18–4.67, 0.12–11.67) |
N (%) patients with suboptimal dosagea | 0 (0.0%) | 21 (26.9) | 21 (26.9) | 6 (15.4%) |