Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa

Table 1 Frequency of G6PD genotypes in 6 primary health care clinics in Vhembe District, Limpopo Province, South Africa

G6PD genotypes: male (X*Y) hemizygous deficient A−, male (XY) normal A+ or B; female (X*X*) homozygous deficient = A−/A−; female (X*X) heterozygous deficient = A+/A− or B/A−; and female (XX) normal = A+/A+, B/B or B/A+
NC = not calculated as all males tested in Madimbo clinic carried the G6PD B variant
* P values < 0.05 indicate significant differences from predicted G6PD allele frequencies in females based on male allele frequencies for A−, A+ and B alleles using the Hardy–Weinberg equation (χ²)

ISSN: 1475-2875