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Table 3 Differences in CSF PfHRP-2 and plasma PfHRP-2 levels by finding for 58 patients with brain magnetic resonance imaging

From: Cerebrospinal fluid Plasmodium falciparum histidine-rich protein-2 in pediatric cerebral malaria

Radiographic finding

N (%) positive

Plasma PfHRP-2, median (IQR)

CSF PfHRP-2, median (IQR)

Positive finding

Negative finding

p valuea

Positive finding

Negative finding

p valuea

Frontal–occipital lobe T2 hyperintensity

6 (10)

37.9 (13.7–65.7)

24.3 (8.5–51.1)

0.72

5782 (2602–21,100)

12,906 (4820–22,569)

0.35

Periventricular T2 hyperintensity

25 (43)

15.2 (0.6–36.4)

31.6 (14.8–65.3)

0.03

11,000 (4258–17,510)

15,094 (5573–28,084)

0.17

Periventricular DWI abnormality

22 (38)

17.7 (8.8–33.3)

32.6 (8.1–64.8)

0.25

9951 (3631–19,172)

14,226 (5542–26,893)

0.27

Subcortical white matter T2 hyperintensity

39 (67)

24.7 (13.5–63.7)

30.1 (2.8–48.1)

0.90

11,000 (5294–21,100)

16,099 (3968–26,906)

0.80

Cortical T2 hyperintensity

47 (81)

27.9 (9.9–48.2)

14.2 (3.8–96.1)

0.77

13,358 (5294–26,879)

10,242 (3595–17,533)

0.20

Cortical DWI abnormality

6 (10)

5.0 (0–27.9)

27.7 (13.6–64.0)

0.06

14,754 (1678–28,084)

11,847 (5403–20,136)

0.69

Caudate T2 hyperintensity

41 (71)

29.1 (13.5–64.3)

15.2 (8.2–43.0)

0.31

13,358 (5862–26,879)

8147 (3968–17,533)

0.13

Caudate DWI abnormality

4 (7)

69.0 (18.5–212.0)

24.3 (8.8–48.2)

0.23

15,390 (11,047–26,981)

11,184 (4274–22,110)

0.51

Globus pallidi T2 hyperintensity

43 (74)

30.1 (13.5–65.3)

14.8 (6.2–35.1)

0.11

15,094 (5863–26,906)

5512 (3968–17,533

0.49

Globus pallidi DWI abnormality

13 (22)

65.3 (26.3–92.7)

19.2 (8.2–46.3)

0.02

15,094 (11,000–36,540)

10,470 (4258–21,100)

0.09

Putamen T2 hyperintensity

42 (72)

29.6 (13.5–64.3)

15.0 (5.5–39.0)

0.19

14,783 (5662–26,906)

6830 (2830–16,816)

0.04

Putamen DWI abnormality

7 (12)

63.7 (13.7–101.6)

23.8 (8.2–48.1)

0.11

13,358 (10,242–36,540)

11,128 (4258–22,110)

0.28

Thalamus T2 hyperintensity

31 (53)

26.3 (8.8–48.2)

19.2 (8.2–65.7)

0.99

13,358 (3902–26,906)

11,000 (5512–17,732)

0.61

Corpus callosum T2 hyperintensity

20 (34)

22.4 (13.7–44.6)

29.0 (2.8–64.3)

0.85

13,852 (5434–21,605)

11,847 (4258–26,906)

0.921

Corpus callosum DWI abnormality

19 (33)

24.7 (13.7–46.3)

27.9 (2.8–64.3)

0.86

17,462 (5573–23,028)

11,240 (3968–18,048)

0.49

Posterior fossa T2 hyperintensity

34 (59)

30.3 (13.5–64.3)

17.2 (4.5–47.9)

0.29

17,486 (5992–28,084)

8442 (4113–16,760)

0.02

Posterior fossa DWI abnormality

4 (7)

50.7 (4.4–207.6)

25.5 (9.9–48.2)

0.74

7526 (852–14,226)

11,847 (5294–23,028)

0.14

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Malaria Journal

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