Cerebrospinal fluid Plasmodium falciparum histidine-rich protein-2 in pediatric cerebral malaria

Malaria Journal

Table 4 Multivariable logistic regression analysis for plasma PfHRP-2, CSF PfHRP-2, and CSF/plasma PfHRP-2 ratio and mortality

Variable^a	Plasma PfHRP-2 model		CSF PfHRP-2 model		CSF/plasma PfHRP-2 model
Variable^a	Odds ratio (95% CI)	p value	Odds ratio (95% CI)	p value	Odds ratio (95% CI)	p value
Age, 6 month increase	1.08 (0.92–1.26)	0.33	1.04 (0.88–1.24)	0.63	1.05 (0.90–1.23)	0.51
Abnormal WBC vs normal	3.29 (0.76–14.17)	0.11	6.61 (1.05–41.73)	0.04	2.94 (0.70–12.26)	0.14
Abnormal lactate vs normal	11.74 (0.76–181.61)	0.08	22.47 (1.07–470.35)	0.04	12.66 (0.82–194.18)	0.07
High plasma PfHRP-2 vs low	2.05 (0.45–9.35)	0.35	–		–	–
High CSF PfHRP-2 vs low	–	–	9.00 (1.44–56.42)	0.02	–
High CSF/plasma PfHRP-2 vs low	–	–	–	–	1.67 (0.35–7.88)	0.52

CI confidence interval, WBC white blood count
^aWhite blood cell count was coded abnormal if ≥ 10,000 cells/μL; lactate was coded abnormal if ≥ 5 mmol/L; PfHRP-2 measures were coded high if in the upper quartile (CSF > 65.309 ng/mL, ratio > 0.00945, plasma > 10,242 ng/mL) and low if less than the upper quartile. Similar results were obtained if these measures were continuous

ISSN: 1475-2875