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Fig. 1 | Malaria Journal

Fig. 1

From: Population pharmacokinetic and pharmacodynamic properties of artesunate in patients with artemisinin sensitive and resistant infections in Southern Myanmar

Fig. 1

Schematic representation of the final population pharmacokinetic-pharmacodynamic model for parent compound (artesunate; ARS) and its active metabolite (dihydroartemisinin; DHA) in patients with uncomplicated P. falciparum malaria. Ce, predicted DHA concentration in the effect compartment; CL, elimination clearance; EC50, the DHA concentration which produces 50% of maximum parasite killing effect; Emax, maximum parasite killing effect; ke0, effect compartment rate constant governing the delayed drug effect; KGROWTH, parasite multiplication rate, fixed to tenfold multiplication per 48-h cycle; KTR, first order transit absorption rate constant; V, apparent volume of distribution

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Malaria Journal

ISSN: 1475-2875

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