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Table 3 Predictive performance of the baseline-adapted nomogram and the day-3 positivity test

From: Population pharmacokinetic and pharmacodynamic properties of artesunate in patients with artemisinin sensitive and resistant infections in Southern Myanmar

Statistics metric Baseline-adapted nomogram Day-3 positivity test
Negative results (N) The nomogram predicts the individual parasite density ratio (Ratio i ) to be above the “Cut-off” Non-resistant if observed parasitaemia is below LLOQ at day 3
Positive results (P) The nomogram predicts the individual parasite density ratio (Ratio i ) to be below the “Cut-off” Resistant if observed parasitaemia is above LLOQ at day 3
True positive (TP) The approach predicts correctly the patient to have a resistant infection
True negative (TN) The approach predicts correctly the patient to have a sensitive infection
Sensitivity \(\frac{TP}{TP + FN}\) Probability of predicting correctly patients with resistant infections 90% 55%
Specificity \(\frac{TN}{TP + FP}\) Probability of predicting correctly patients with sensitive infections 95% 95%
Accuracy \(\frac{TP + TN}{TP + TN + FP + FN}\) Proportion of all correct predictions 93% 75%