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Table 1 Susceptibility of NF54, NF54ART, Dd2, and Dd2SC to SC83288 and artemisinin

From: Profiling of the anti-malarial drug candidate SC83288 against artemisinins in Plasmodium falciparum

Strain

IC50 (nM)

SC83288

Dihydroartemisinin

NF54

5.1 ± 0.7

0.7 ± 0.1

NF54ART

4.9 ± 0.8

0.5 ± 0.1

Dd2

3.1 ± 0.2

0.7 ± 0.1

Dd2SC

1000 ± 200*

0.5 ± 0.5

  1. IC 50 inhibitory concentration of 50% of the maximal effect. Mean ± SEM of 6–13 independent biological replicates
  2. *p < 0.001 as compared with the parental strain