New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum

Malaria Journal

Table 2 In vivo anti-malarial activity against Plasmodium berghei

Compound	Dose (mg/kg/day)	Mean parasitaemia ± SD (% inhibition of parasite growth)^b
Compound	Dose (mg/kg/day)	Day 5	Day 7	Day 10
Control^a		1.51 ± 0.22	3.58 ± 0.81	5.65 ± 0.43
LC92	50	0.02 ± 0.05 (98.34)	0.46 ± 0.60 (86.99)	0.77 ± 0.26 (86.27)
LC129	50	0.19 ± 0.12 (87.60)	1.76 ± 1.36 (50.69)	1.32 ± 1.24 (76.67)
LC130	50	0 (100)	1.4 ± 0.94 (60.83)	1.32 ± 0.24 (76.67)
LC131	50	0 (100)	0 (100)	0 (100)
LC132	50	0 (100)	0 (100)	0.31 ± 0.10 (94.46)
LC136	50	0 (100)	0 (100)	0 (100)
MIS13	50	0.11 ± 0.19 (92.56)	0.05 ± 0.10 (98.60)	0 (100)
LC163	50	0 (100)	0 (100)	0.2 ± 0.13 (96.46)

ISSN: 1475-2875