Table 2 Parasitaemia, chemo suppression and survival days of mice treated with different combination concentrations of cryptolepine/xylopic acid for 5 days
Treatment | Dose (mg kg−1) | % parasitaemia | % chem supp | Survival |
|---|---|---|---|---|
Day 1 | Day 6 | Days | ||
Vehicle | 0.50 ml | 19.2 ± 4.1 | – | 9.2 ± 0.8 |
CYP + XA | 15 + 11 | 21.5 ± 3.3 | 78.2 ± 2.9 | 18.0 ± 1.4 |
CYP + XA | 7.5 + 5.5 | 19.2 ± 2.7 | 67.0 ± 0.1 | 15.3 ± 0.6 |
CYP + XA | 3.8 + 2.8 | 20.1.1 ± 2.0 | 65.5 ± 2.6 | 15 ± 1.8 |
CYP + XA | 1.9 + 1.4 | 18.5 ± 3.1 | 50.6 ± 2.4 | 13.3 ± 1.4 |
CYP + XA | 0.9 + 0.7 | 18.2 ± 1.3 | 40.0 ± 1.5 | 14.0 ± 2.5 |
ART + LUM (positive control) | 1.14 + 16.9 | 21.3 ± 57.9 | 90.3 ± 1.7 | 25.2 ± 1.3 |