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Table 2 Parasitaemia, chemo suppression and survival days of mice treated with different combination concentrations of cryptolepine/xylopic acid for 5 days

From: Isobolographic analysis of co-administration of two plant-derived antiplasmodial drug candidates, cryptolepine and xylopic acid, in Plasmodium berghei

Treatment Dose (mg kg−1) % parasitaemia % chem supp Survival
Day 1 Day 6 Days
Vehicle 0.50 ml 19.2 ± 4.1 9.2 ± 0.8
CYP + XA 15 + 11 21.5 ± 3.3 78.2 ± 2.9 18.0 ± 1.4
CYP + XA 7.5 + 5.5 19.2 ± 2.7 67.0 ± 0.1 15.3 ± 0.6
CYP + XA 3.8 + 2.8 20.1.1 ± 2.0 65.5 ± 2.6 15 ± 1.8
CYP + XA 1.9 + 1.4 18.5 ± 3.1 50.6 ± 2.4 13.3 ± 1.4
CYP + XA 0.9 + 0.7 18.2 ± 1.3 40.0 ± 1.5 14.0 ± 2.5
ART + LUM (positive control) 1.14 + 16.9 21.3 ± 57.9 90.3 ± 1.7 25.2 ± 1.3
  1. Values are mean ± SEM