Marker
|
n (%)
|
---|
Benguela
|
Zaire
|
Lunda Sul
|
---|
DP
|
ASAQ
|
AL
|
ASAQ
|
AL
|
---|
Reinf day 0
|
Reinf day failure
|
Reinf day 0
|
Reinf day failure
|
Reinf day 0
|
Reinf day failure
|
Recr day 0
|
Recr day failure
|
Reinf day 0
|
Reinf day failure
|
Recr day 0
|
Recr day failure
|
Reinf day 0
|
Reinf day failure
|
Recr day 0
|
Recr day failure
|
---|
n = 5
|
n = 5
|
n = 1
|
n = 1
|
n = 3
|
n = 3
|
n = 4
|
n = 4
|
n = 11
|
n = 11
|
n = 5
|
n = 5
|
n = 6
|
n = 6
|
n = 3
|
n = 3
|
---|
pfk13 sequence
|
Wildtype
|
5 (100)
|
5 (100)
|
1 (100)
|
1 (100)
|
2 (67)
|
3 (100)
|
4 (100)
|
4 (100)
|
11 (100)
|
11 (100)
|
5 (100)
|
5 (100)
|
6 (100)
|
6 (100)
|
3 (100)
|
3 (100)
|
A504V
|
–
|
–
|
–
|
–
|
1 (33)
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
pfcrt sequencea
|
CVMNK
|
2 (40)
|
4 (80)
|
–
|
–
|
1 (33)
|
3 (100)
|
1 (25)
|
3 (75)
|
5 (45)
|
–
|
2 (40)
|
–
|
6 (100)
|
5 (83)
|
3 (100)
|
3 (100)
|
CVIET
|
4 (80)
|
1 (20)
|
1 (100)
|
1 (100)
|
2 (67)
|
–
|
3 (75)
|
2 (50)
|
7 (64)
|
11 (100)
|
5 (100)
|
5 (100)
|
1 (17)
|
1 (17)
|
–
|
–
|
pfmdr1 sequenceb
|
NYD
|
4 (80)
|
5 (100)
|
1 (100)
|
1 (100)
|
3 (100)
|
2 (67)
|
4 (100)
|
3 (75)
|
5 (45)
|
7 (64)
|
4 (80)
|
5 (100)
|
6 (100)
|
5 (83)
|
2 (67)
|
2 (67)
|
NFD
|
1 (20)
|
–
|
–
|
–
|
–
|
1 (33)
|
–
|
1 (25)
|
6 (55)
|
2 (18)
|
1 (20)
|
–
|
–
|
1 (17)
|
2 (67)
|
2 (67)
|
YFD
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
–
|
2 (18)
|
–
|
–
|
–
|
–
|
–
|
–
|
pfmdr1 copy number
|
1
|
5 (100)
|
5 (100)
|
1 (100)
|
1 (100)
|
3 (100)
|
3 (100)
|
4 (100)
|
4 (100)
|
11 (100)
|
11 (100)
|
5 (100)
|
5 (100)
|
6 (100)
|
6 (100)
|
3 (100)
|
3 (100)
|
plasmepsin 2 copy number
|
1
|
5 (100)
|
5 (100)
|
1 (100)
|
1 (100)
|
3 (100)
|
3 (100)
|
4 (100)
|
4 (100)
|
11 (100)
|
11 (100)
|
5 (100)
|
5 (100)
|
6 (100)
|
6 (100)
|
3 (100)
|
3 (100)
|
- Reinf reinfection, Recr recrudescence, AL artemether–lumefantrine, ASAQ artesunate–amodiaquine, DP dihydroartemisinin–piperaquine
- apfcrt haplotype classified according to amino acids at positions 72, 73, 74, 75, and 76; mixed infections were included in the numerator for each haplotype
- bpfmdr1 haplotype classified according to amino acids at positions 86, 184, and 1246; mixed infections were included in the numerator for each haplotype