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Table 5 Molecular markers of resistance for treatment failures observed during therapeutic efficacy monitoring in Angola, 2017

From: Efficacy and safety of artemether–lumefantrine, artesunate–amodiaquine, and dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in three provinces in Angola, 2017

Marker n (%)
Benguela Zaire Lunda Sul
DP ASAQ AL ASAQ AL
Reinf day 0 Reinf day failure Reinf day 0 Reinf day failure Reinf day 0 Reinf day failure Recr day 0 Recr day failure Reinf day 0 Reinf day failure Recr day 0 Recr day failure Reinf day 0 Reinf day failure Recr day 0 Recr day failure
n = 5 n = 5 n = 1 n = 1 n = 3 n = 3 n = 4 n = 4 n = 11 n = 11 n = 5 n = 5 n = 6 n = 6 n = 3 n = 3
pfk13 sequence
 Wildtype 5 (100) 5 (100) 1 (100) 1 (100) 2 (67) 3 (100) 4 (100) 4 (100) 11 (100) 11 (100) 5 (100) 5 (100) 6 (100) 6 (100) 3 (100) 3 (100)
 A504V – – – – 1 (33) – – – – – – – – – – –
pfcrt sequencea
 CVMNK 2 (40) 4 (80) – – 1 (33) 3 (100) 1 (25) 3 (75) 5 (45) – 2 (40) – 6 (100) 5 (83) 3 (100) 3 (100)
 CVIET 4 (80) 1 (20) 1 (100) 1 (100) 2 (67) – 3 (75) 2 (50) 7 (64) 11 (100) 5 (100) 5 (100) 1 (17) 1 (17) – –
pfmdr1 sequenceb
 NYD 4 (80) 5 (100) 1 (100) 1 (100) 3 (100) 2 (67) 4 (100) 3 (75) 5 (45) 7 (64) 4 (80) 5 (100) 6 (100) 5 (83) 2 (67) 2 (67)
 NFD 1 (20) – – – – 1 (33) – 1 (25) 6 (55) 2 (18) 1 (20) – – 1 (17) 2 (67) 2 (67)
 YFD – – – – – – – – – 2 (18) – – – – – –
pfmdr1 copy number
 1 5 (100) 5 (100) 1 (100) 1 (100) 3 (100) 3 (100) 4 (100) 4 (100) 11 (100) 11 (100) 5 (100) 5 (100) 6 (100) 6 (100) 3 (100) 3 (100)
plasmepsin 2 copy number
 1 5 (100) 5 (100) 1 (100) 1 (100) 3 (100) 3 (100) 4 (100) 4 (100) 11 (100) 11 (100) 5 (100) 5 (100) 6 (100) 6 (100) 3 (100) 3 (100)
  1. Reinf reinfection, Recr recrudescence, AL artemether–lumefantrine, ASAQ artesunate–amodiaquine, DP dihydroartemisinin–piperaquine
  2. apfcrt haplotype classified according to amino acids at positions 72, 73, 74, 75, and 76; mixed infections were included in the numerator for each haplotype
  3. bpfmdr1 haplotype classified according to amino acids at positions 86, 184, and 1246; mixed infections were included in the numerator for each haplotype
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Malaria Journal

ISSN: 1475-2875

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